Copper Oxide Nanoparticles Stimulate Cellular Damage and Histological Architecture Deterioration in Tissues of Culex Pipiens Larvae (Diptera: Culicidae).

, is one of the considerable vector-borne diseases widely distributed all over world. The extensive use synthetic insecticides caused various human health hazardous, insect resistance and environmental pollution. As an alternative control strategy, nanoparticle applications in management are mandatory. Mainly, aim this current study to elucidate toxic effect copper oxide nanoparticles (CuONPs) on larval tissues Culex pipiens regarding histological cellular damage aspects. lethal concentrations LC10, LC25, LC50 LC90 were determined from established regression log concentrate-response lines after 24 hours treatment. Four replicates considered for each concentration where twenty-five third instar larvae involved replicate. Results revealed significant increase mortality rate upon increasing which recorded 0.040, 0.099, 0.268 1.767 mg/ ml LC 25, LC50, respectively. Data showed a enzyme levels namely, lipid peroxidase nitric oxide, decrease total protein while, albumin proportions detected tissue homogenates treated mentioned CuONPs concentrations. Meanwhile, studies implied severe deterioration architecture increases markedly as well. In conclusion, deteriorate structure render them promising smart larvicidal agents.